Title
Seven-valent pneumococcal conjugate vaccine and nasopharyngeal microbiota in healthy children
Author
Biesbroek, G.
Wang, X.
Keijser, B.J.F.
Eijkemans, R.M.J.
Trzciński, K.
Rots, N.Y.
Veenhoven, R.H.
Sanders, E.A.M.
Bogaert, D.
Publication year
2014
Abstract
Seven-valent pneumococcal conjugate vaccine (PCV- 7) is effective against vaccine serotype disease and carriage. Nevertheless, shifts in colonization and disease toward nonvaccine serotypes and other potential pathogens have been described. To understand the extent of these shifts, we analyzed nasopharyngeal microbial profiles of 97 PCV-7-vaccinated infants and 103 control infants participating in a randomized controlled trial in the Netherlands. PCV-7 immunization resulted in a temporary shift in microbial community composition and increased bacterial diversity. Immunization also resulted in decreased presence of the pneumococcal vaccine serotype and an increase in the relative abundance and presence of nonpneumococcal streptococci and anaerobic bacteria. Furthermore, the abundance of Haemophilus and Staphylococcus bacteria in vaccinees was increased over that in controls. This study illustrates the much broader effect of vaccination with PCV- 7 on the microbial community than currently assumed, and highlights the need for careful monitoring when implementing vaccines directed against common colonizers.
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Biomedical Innovation
Biology
MSB - Microbiology and Systems Biology
To reference this document use:
http://resolver.tudelft.nl/uuid:c7069935-b965-4277-bd40-7cf5899bb06f
DOI
https://doi.org/10.3201/eid2002.131220
TNO identifier
488264
ISSN
1080-6040
Source
Emerging Infectious Diseases, 20 (20), 201-210
Document type
article