Print Email Facebook Twitter Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins: The ears study Title Interactions between lifestyle-related factors and the ApoE polymorphism on plasma lipids and apolipoproteins: The ears study Author Boer, J.M.A. Ehnholm, C. Menzel, H.J. Havekes, L.M. Rosseneu, M. O'Reilly, D.S.J. Tiret, L. Gaubius Instituut TNO Publication year 1997 Abstract To elucidate how the apolipoprotein (apo)E polymorphism and modifiable factors interact in explaining plasma lipid and apolipoprotein levels, we studied 1448 young adults (18 to 26 years old), participating in the European Atherosclerosis Research Study (EARS). Venous blood was collected after an overnight fast. Modifiable factors, eg, body mass index (BMI), waist-to-hip ratio (WHR), tobacco and alcohol consumption, and physical activity, were determined by using standardized protocols. Associations of modifiable factors with apoE levels were homogeneous across apoE phenotypes. In contrast, correlations of BMI with total cholesterol and apoB levels, as well as correlations between WHR and apoB, were significantly (P<.05 to P<.01) stronger in E2 carriers than in subjects with other phenotypes. Total cholesterol and apoB levels were comparable in E2 carriers in the upper tertile of BMI or WHR to those in E3/3 subjects, suggesting that the lowering effect of the E2 allele was no longer present. The inverse association between the plasma cholesteryl linoleate-to-oleate ratio, a marker for the dietary polyunsaturated-to-saturated fatty acid ratio, and triglycerides was also stronger in E2 carriers (-0.33 versus -0.17 in E3/3 and -0.24 in E4 carriers). Associations with other modifiable factors were notably consistent across apoE phenotypes. Gender and modifiable factors explained three times more (31%) of the interindividual variation in apoB levels in E2 carriers than in E3/3 subjects (9%) or E4 carriers (14%), mainly due to a larger variance explained by BMI. Our results suggest that the apoE polymorphism acts in a relatively uniform manner, independently of lifestyle. However, the associations of adiposity to total cholesterol and apoB levels appear to be stronger in apoE2 carriers. Chemicals/CAS: Apolipoprotein E4; Apolipoproteins B; Apolipoproteins E; Apolipoproteins; Cholesterol Esters; cholesteryl linoleate, 604-33-1; cholesteryl oleate, 303-43-5; Lipids Subject BiologyAdiposityApolipoproteinApolipoprotein E polymorphismLifestyleLipidsApolipoproteinApolipoprotein bApolipoprotein eApolipoprotein e2Apolipoprotein e3CholesterolCholesterol oleateLinoleic acidLipidPolyunsaturated fatty acidSaturated fatty acidTriacylglycerolAdultAlcohol consumptionAnthropometryBody massCigarette smokingControlled studyFemaleGenetic polymorphismHumanLifestyleLipid blood levelMajor clinical studyMalePhenotypePhysical activityPriority journalAdolescentAdultApolipoprotein E4ApolipoproteinsApolipoproteins BApolipoproteins EBody Mass IndexCholesterol EstersCoronary ArteriosclerosisFemaleHeterozygoteHumansLife StyleLipidsMalePolymorphism, GeneticRisk Factors To reference this document use: http://resolver.tudelft.nl/uuid:c52395cc-953a-40c6-87ed-0b8d7d5cb690 TNO identifier 234084 ISSN 1079-5642 Source Arteriosclerosis, Thrombosis, and Vascular Biology, 17 (9), 1675-1681 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.