Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies

Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies

Gezondheidsorganisatie TNO Gaubius Instituut TNO
Schielen, W.J.G.
Adams, H.P.H.M.
Nieuwenhuizen, W.
Tesser, G.J.

1991

The Mpc‐group has a somewhat better stability than the Fmoc‐group, resists catalytic hydrogenolysis, is highly stable in acidic media and its elimination product does not polymerize spontaneously. In a direct comparison of coupling efficiencies obtained in solid phase peptide syntheses using Mpc‐ or Fmoc‐amino acids it is shown that the use of Mpc‐amino acids leads to better coupling efficiencies and, consequently, a more homogeneous peptide. An improved synthesis of Mpc‐ONSu and of Mpc‐amino acid derivatives is presented.

Coupling efficiency
Mpc-amino acid
Plasminogen activation
Solid phase peptide synthesis

http://resolver.tudelft.nl/uuid:c4e7a847-b74f-49d4-9685-9e68f111abb6

https://doi.org/10.1111/j.1399-3011.1991.tb00748.x

268098

International journal of peptide and protein research, 37 (37), 341-346

article