Print Email Facebook Twitter Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies Title Use of Mpc-amino acids in solid phase peptide synthesis leads to improved coupling efficiencies Author Gezondheidsorganisatie TNO Gaubius Instituut TNO Schielen, W.J.G. Adams, H.P.H.M. Nieuwenhuizen, W. Tesser, G.J. Publication year 1991 Abstract The Mpc‐group has a somewhat better stability than the Fmoc‐group, resists catalytic hydrogenolysis, is highly stable in acidic media and its elimination product does not polymerize spontaneously. In a direct comparison of coupling efficiencies obtained in solid phase peptide syntheses using Mpc‐ or Fmoc‐amino acids it is shown that the use of Mpc‐amino acids leads to better coupling efficiencies and, consequently, a more homogeneous peptide. An improved synthesis of Mpc‐ONSu and of Mpc‐amino acid derivatives is presented. Subject Coupling efficiencyMpc-amino acidPlasminogen activationSolid phase peptide synthesis To reference this document use: http://resolver.tudelft.nl/uuid:c4e7a847-b74f-49d4-9685-9e68f111abb6 DOI https://doi.org/10.1111/j.1399-3011.1991.tb00748.x TNO identifier 268098 Source International journal of peptide and protein research, 37 (37), 341-346 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.