Print Email Facebook Twitter Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone Title Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone Author Hellgren, M. Conard, J. Norris, L. Kluft, C. TNO Kwaliteit van Leven Publication year 2009 Abstract Objective: To study cardiovascular risk markers in women taking estradiol/trimegestone or estradiol/dydrogesterone. Design: Multicenter, randomized, prospective, double-blind study of 184 healthy post-menopausal women randomized to 6 cycles of either estradiol (2 mg) + trimegestone (0.5 mg) (T-group) or estradiol (2 mg) + dydrogesterone (10 mg) (DYDR group). Cardiovascular risk markers were measured before, after cycle 1, 3 and 6 and at 4 weeks post-treatment. Results: Fibrinogen was reduced in both groups but more markedly in the DYDR group. Factor VIIc activity levels decreased in both groups with a greater change in the T-group. Factor VII antigen was increased in both groups with a greater increase in the DYDR group. Factor VIIa was increased in the DYDR group only. Plasminogen levels were also increased in both groups with a greater increase in the T-group. There were no statistically significant changes in lipid variables between the different regimens. Changes in total cholesterol and LDL cholesterol were correlated positively with changes in factor VIIc in the DYDR group and negatively with changes in factor VIIc in the T-group. Trigemestone was associated with a better bleeding pattern. Conclusions: Trimegestone was associated with less procoagulant changes in factor VIIa and factor VIIc activity and larger decrease in PAI-1 activity compared with the dydrogesterone preparation. These results reflect less androgenic properties of the trimegestone preparation. The fibrinogen level and Lp(a) were more decreased during dydrogesterone treatment. Further investigation is required to clarify the relative importance of beneficial effects with respect to cardiovascular risk. © 2009. Subject BiologyBiomedical ResearchBlood coagulationCardiovascular riskEndometrial protectionFibrinolysisHormone therapyLipidsMenopausedydrogesteroneestradiolgestagenlow density lipoprotein cholesteroltrimegestoneadultarticlecardiovascular riskcholesterol blood levelclinical trialcontrolled clinical trialcontrolled studydouble blind proceduredrug effectfemalefibrinolysishumanmajor clinical studypostmenopauserandomized controlled trialAdultAgedBiological MarkersBlood Coagulation FactorsCardiovascular DiseasesDouble-Blind MethodDrug Therapy, CombinationDydrogesteroneEstradiolEstrogen Replacement TherapyEstrogensFemaleFibrinolysisHumansLipidsMiddle AgedPostmenopauseProgestinsPromegestoneRisk FactorsThromboembolismUterine Hemorrhage To reference this document use: http://resolver.tudelft.nl/uuid:c4b342c6-9c4c-4ad4-80fb-40babc72f1f1 DOI https://doi.org/10.1016/j.maturitas.2009.01.004 TNO identifier 241444 ISSN 0378-5122 Source Maturitas, 62 (3), 287-293 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.