Print Email Facebook Twitter Non-differential underestimation may cause a threshold effect of exposure to appear as a dose-response relationship Title Non-differential underestimation may cause a threshold effect of exposure to appear as a dose-response relationship Author Verkerk, P.H. Buitendijk, S.E. Nederlands Instituut voor Praeventieve Gezondheidszorg TNO Publication year 1992 Abstract It is generally believed that non-differential misclassification will lead to a bias toward the null-value. However, using one graphical and one numerical example, we show that in situations where underestimation more than overestimation is the problem, non-differential misclassification may lead to a bias away from the null-value for intermediate categories of exposure variables. We show that a true threshold level for an exposure may, subsequently, appear as a dose-response relationship. Underestimation more than overestimation is likely to occur in studies in which self-reports are used to obtain data on activities which respondents voluntarily engage in and which are socially not acceptable or known to be potentially dangerous. Researchers should be aware that both a shown deleterious effect at a low level of exposure and a dose-response relationship may in fact be spurious and due to underestimation of exposure at higher levels. Subject HealthMethodologyMisclassificationNon-differentialUnderestimationData analysisDose responseBias (Epidemiology)Child, PreschoolComparative StudyDose-Response Relationship, DrugEpidemiologic MethodsFemaleHumanPregnancyPrenatal Exposure Delayed EffectsResearch To reference this document use: http://resolver.tudelft.nl/uuid:bfaa40d2-af75-4db9-a671-625b0c6d1d80 DOI https://doi.org/10.1016/0895-4356(92)90103-t TNO identifier 231905 ISSN 0895-4356 Source Journal of Clinical Epidemiology, 45 (5), 543-545 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.