Title
Sensitivity of several cell systems to acrylamide
Author
Medisch Biologisch Laboratorium TNO
Hooisma, J.
Groot, D.M.G.de
Magchielse, T.
Muijser, H.
Publication year
1980
Abstract
Chick spinal ganglia, chick muscle cells combined with mouse spinal cord explants, C1300 neuroblastoma cells, Chinese hamster ovary cells and newborn rat cerebral cells were exposed to various concentrations of acrylamide in culture. Four morphological and 1 electrophysiological parameter were applied in order to score toxic effects. It appeared that the neurite formation of rat cerebral neurons was the most sensitive criterion showing an effect at 10-7 M acrylamide. Chemicals/CAS: acrylamide, 79-06-1; Acrylamides
Subject
Historisch materiaal TNO
Central nervous system
Cytotoxicity
Dose response
Drug response
Endocrine system
Female genital system
Histology
In vitro study
Intoxication
Muscle cell
Nervous system
Neuroblastoma cell
Neurotoxicity
Ovary cell
Rat
Spinal cord
Spinal ganglion
Acrylamides
Animal
Brain
Chickens
Ganglia, Spinal
Mice
Muscles
Neurons
Rabbits
Tissue Culture
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DOI
https://doi.org/10.1016/0300-483x(80)90089-x
TNO identifier
228933
ISSN
0300-483X
Source
Toxicology, 17 (17), 161-167
Bibliographical note
Ook als rapport uitgegeven maar geen nummer bekend
Document type
article