Workplace Innovation is an integral set of participative mechanisms for interventions relating structural (e.g., organisational design) and cultural aspects (e.g., leadership, coordination and organisational behaviour) of the organisation and its people with the objective to simultaneously improve the conditions for the performance (i.e., productivity, innovation, quality) and quality of working life (i.e., wellbeing at work, competence development, employee engagement). The two cases are different in their motivation and the goals they want to achieve. For Buurtzorg NL the service delivered to clients is a central goal, and the way to do that is to provide the employees the professional autonomy and facilities to deliver this service. As a consequence the job quality is very high as well. For CTS, the customers are central too. CTS employees want to develop the best technological solutions for them, but they also want to excel and apply the new knowledge elsewhere. They also want to perform a sustainable business, while at the same time their goal is to grow and be economically profitable. Both organisations have in common that their workplace innovation measures are firmly grounded in change of a structural nature. These organisations have changed the organisational structure, the division of labour and management responsibility, in favour of more professional autonomy and a larger voice for the employees at shopfloor level. This structural change was aligned by cultural adaptation, such as the style of leadership, inter-human communication and cooperation (in a team-based context), and behaviour that fits with ‘mature’ employment relationships. Consequently these structural and cultural adaptations enabled an easier adoption of new technology and changes, because the employees have become highly involved in redesigning the organisation and contributing to innovation. They were involved in the development and implementation of new technology. Thus technology does not take over their work but supports them in performing their work and/or makes it possible to improve the quality of the work delivered.