Title
Epigallocatechin gallate (EGCG) (TEAVIGO™) does not impair nonhaem-iron absorption in man
Author
Ullmann, U.
Haller, J.
Bakker, G.C.M.
Brink, E.J.
Weber, P.
TNO Kwaliteit van Leven
Publication year
2005
Abstract
A number of studies have shown that tea catechins can inhibit intestinal iron absorption, mostly iron in the nonhaem form. This randomized, double-blind, placebo-controlled, 3-periods cross-over study examined the degree of inhibition of nonhaem iron absorption by pure crystalline epigallocatechin gallate (EGCG). The study was designed to show the maximum inhibitory action of EGCG by selecting 30 healthy women with low iron stores. Treatments were 150 mg, 300 mg EGCG and placebo each for 8 consecutive study days with a wash-out period of 14 days between treatments. Iron incorporation was assessed by supplying 57Fe orally and 58Fe intravenously. Differences in fractional nonhaem iron absorption between the treatments were evaluated by using two-sided ANOVA. Results showed a relative nonhaem iron absorption reduction of 14% with 150 mg EGCG and 27% for 300 mg EGCG treatment compared to placebo. Differences were statistically significant (p≤0.05) between the placebo and the 300 mg EGCG treatments and between the 150 and 300 mg EGCG treatments. The inverse relation between EGCG dose and fractional nonhaem iron absorption was linear (p=0.0002). In this study the magnitude of the inhibitory action of EGCG on nonhaem iron absorption was found to be much lower than that reported in the literature for black tea and similar compounds. The doses of EGCG in supplements, which will be lower than those used in this study, are not expected to have any health relevant effects on iron absorption in subjects with normal iron stores. © 2005 Elsevier GmbH. All rights reserved.
Subject
Biology
Biomedical Research
Double blind
Epigallocatechin gallate (EGCG)
Green tea catechins
Iron absorption
Placebo-controlled 3-periods cross over study in man
Randomized
Epigallocatechin gallate
Ferrous ion
Iron
Placebo
Teavigo
Adult
Analysis of variance
Clinical trial
Controlled clinical trial
Controlled study
Crossover procedure
Dose response
Double blind procedure
Female
Human
Iron absorption
Iron storage
Malabsorption
Normal human
Priority journal
Randomized controlled trial
Statistical significance
Tea
Administration, Oral
Adolescent
Adult
Antioxidants
Camellia sinensis
Catechin
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Interactions
Female
Humans
Injections, Intravenous
Intestinal Absorption
Iron
Iron Isotopes
Middle Aged
Phytotherapy
Camellia sinensis
To reference this document use:
http://resolver.tudelft.nl/uuid:bd5a8dff-78a9-497c-aeb2-2f38956ee9be
DOI
https://doi.org/10.1016/j.phymed.2004.07.001
TNO identifier
238551
ISSN
0944-7113
Source
Phytomedicine, 12 (6-7), 410-415
Document type
article