Print Email Facebook Twitter Idiopathic paraproteinemia. III. Increased frequency of paraproteinemia in thymectomized aging C57BL/KaLwRij and CBA/BrARij mice Title Idiopathic paraproteinemia. III. Increased frequency of paraproteinemia in thymectomized aging C57BL/KaLwRij and CBA/BrARij mice Author Radl, J. de Glopper, E. van den Berg, P. van Zwieten, M.J. Instituut voor experimentele gerontologie TNO Publication year 1980 Abstract The influence of thymectomy on the appearance of idiopathic paraproteinemia (IP) during aging was investigated in mice of the C57BL/KaLwRij and CBA/BrARij strains, which under normal conditions develop IP in high and low frequency, respectively. Compared with sham-thymectomized mice, C57BL mice thymectomized at a young adult age showed a markedly increased frequency and an earlier onset of IP during aging; this was even more pronounced in neonatally thymectomized mice. A similar effect of thymectomy was also observed in mice of the CBA strain. Restriction in the heterogeneity of the serum immunoglobulins and the appearance of transient homogenenous Ig components was another frequent finding and this often preceded the appearance of IP in mice of both strains. Thymectomy did not substantially influence either the incidence of paraproteinemias due to a B cell malignancy or the isotope distribution among the paraproteins produced. The results are compatible with the hypothesis that IP develops in three stages as a consequence of an age-related immunodeficiency that primarily affects the T immune system. Chemicals/CAS: Immunoglobulins; Immunoglobulins, kappa-Chain; Immunoglobulins, lambda-Chain Subject AgingAnimalCross ReactionsFemaleImmunoglobulinsImmunoglobulins, kappa-ChainImmunoglobulins, lambda-ChainMaleMiceMice, Inbred C57BLMice, Inbred CBAParaproteinemiasThymectomy To reference this document use: http://resolver.tudelft.nl/uuid:ba939ecd-9dd9-4d80-996a-ff64f39c41f1 TNO identifier 228804 ISSN 0022-1767 Source Journal of Immunology, 125 (1), 31-35 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.