Title
Advanced REACH Tool (ART): Overview of version 1.0 and research needs
Author
Tielemans, E.
Warren, N.
Fransman, W.
van Tongeren, M.
McNally, K.
Tischer, M.
Ritchie, P.
Kromhout, H.
Schinkel, J.
Schneider, T.
Cherrie, J.W.
TNO Kwaliteit van Leven
Publication year
2011
Abstract
This paper provides an outline of the Advanced REACH Tool (ART) version 1.0 and a discussion of how it could be further developed. ART is a higher tier exposure assessment tool that combines mechanistically modelled inhalation exposure predictions with available exposure data using a Bayesian approach. ART assesses exposure for scenarios across different plants and sites. Estimates are provided for different percentiles of the exposure distribution and confidence intervals around the estimate. It also produces exposure estimates in the absence of data, but uncertainty of the estimates will decrease when results of exposure measurements are included. The tool has been calibrated using a broad range of exposure data and provides estimates for exposure to vapours, mists, and dusts. ART has a robust and stable conceptual basis but will be refined in the future and should therefore be considered an evolving system. High-priority areas for future research are identified in this paper and include the integration of partially analogous measurement series, inclusion of company and site-specific assessments, user decision strategies linked to ART predictions, evaluation of validity and reliability of ART, exploring the possibilities for incorporating the dermal route and integration of ART predictions with tools for modelling internal dose. ART is initially developed in the scope of REACH but is equally useful for exposure assessment in other areas. © The Author 2011.
Subject
Healthy Living Life
WE - Work & Employment QS - Quality & Safety
BSS - Behavioural and Societal Sciences Themalijn
Nutrition
Bayesian analysis
exposure modelling
uncertainty
To reference this document use:
http://resolver.tudelft.nl/uuid:ba570212-623e-43d9-a51c-b4c9be109c09
DOI
https://doi.org/10.1093/annhyg/mer094
TNO identifier
442966
ISSN
0003-4878
Source
Annals of Occupational Hygiene, 55 (9), 949-956
Document type
article