Print Email Facebook Twitter Looking back into the future: 30 years of metabolomics at TNO Title Looking back into the future: 30 years of metabolomics at TNO Author van der Greef, J. van Wietmarschen, H. van Ommen, B. Verheij, E.R. Publication year 2013 Abstract Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application-oriented and allowed the development of new profiling technologies. Since 1980, TNO has performed system-based metabolic profiling of body fluids, and combined with pattern recognition has led to many discoveries and contributed to the field known as metabolomics and systems biology. This review describes the development of related concepts and applications at TNO in the biomedical, pharmaceutical, nutritional, and microbiological fields, and provides an outlook for the future. © 2013 Wiley Periodicals, Inc. Rapid Commun. Mass Spectrom. 32: 399-415, 2013. © 2013 Wiley Periodicals, Inc. Subject LifeMSB - Microbiology and Systems Biology QS - Quality & SafetyEELS - Earth, Environmental and Life SciencesFood and NutritionNutritionHealthy Livinganalytical chemistrymetabolomicspattern recognitionsystems biology To reference this document use: http://resolver.tudelft.nl/uuid:b9031412-db86-4a7b-804d-79a33553b8dc DOI https://doi.org/10.1002/mas.21370 TNO identifier 478822 ISSN 0277-7037 Source Mass Spectrometry Reviews, 32 (5), 399-415 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.