Title
Looking back into the future: 30 years of metabolomics at TNO
Author
van der Greef, J.
van Wietmarschen, H.
van Ommen, B.
Verheij, E.R.
Publication year
2013
Abstract
Metabolites have played an essential role in our understanding of life, health, and disease for thousands of years. This domain became much more important after the concept of metabolism was discovered. In the 1950s, mass spectrometry was coupled to chromatography and made the technique more application-oriented and allowed the development of new profiling technologies. Since 1980, TNO has performed system-based metabolic profiling of body fluids, and combined with pattern recognition has led to many discoveries and contributed to the field known as metabolomics and systems biology. This review describes the development of related concepts and applications at TNO in the biomedical, pharmaceutical, nutritional, and microbiological fields, and provides an outlook for the future. © 2013 Wiley Periodicals, Inc. Rapid Commun. Mass Spectrom. 32: 399-415, 2013. © 2013 Wiley Periodicals, Inc.
Subject
Life
MSB - Microbiology and Systems Biology QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Food and Nutrition
Nutrition
Healthy Living
analytical chemistry
metabolomics
pattern recognition
systems biology
To reference this document use:
http://resolver.tudelft.nl/uuid:b9031412-db86-4a7b-804d-79a33553b8dc
DOI
https://doi.org/10.1002/mas.21370
TNO identifier
478822
ISSN
0277-7037
Source
Mass Spectrometry Reviews, 32 (5), 399-415
Document type
article