Title
Efficacy of HI-6 and HLÖ-7 in preventing incapacitation following nerve agent poisoning
Author
TNO Pharma
Melchers, B.P.C.
Philippens, I.H.C.H.M.
Wolthuis, O.L.
Publication year
1994
Abstract
The therapeutic efficacy of the oximes HI-6 and HLo-7 (132.5 μmol/kg), in combination with atropine, in soman- or tabun-intoxicated guinea pigs was compared, particularly with respect to recovery of shuttlebox performance and electroencephalograms (EEGs). After 1.5 x LD50 soman SC, therapy with HI-6 or HLo-7 resulted in survival of 87.5% of the animals in each group. In both groups postintoxication performance decrements and EEG abnormalities lasted approximately 2 weeks after intoxication. After 3 x LD50 soman all HLo-7-treated animals died within 5 h; 70% of the HI-6-treated animals were still alive after 8 h; however, only 10% survived more than 24 h. After 2 x LD50 tabun 36% of the HI-6-treated animals died; HLo-7 prevented lethality and led to faster recovery of performance and EEG than after HI-6. Even after 7.5 x LD50 tabun, followed by HLo-7, full recovery was reached within 1 week in the surviving animals (82%). In soman-intoxicated guinea pigs HI-6 is therapeutically slightly more effective than HLo-7. HLo-7 is far more effective, under similar conditions, against tabun intoxication than HI-6.
Subject
Behavioral performance
EEG
Postintoxication incapacitation
1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether
1 [2,4 bis(hydroxyiminomethyl)pyridinio] 1' (4 carbamoylpyridinio)dimethyl ether diiodide
Atropine
Nerve gas
Oxime derivative
Animal experiment
Controlled study
Drug efficacy
Electroencephalogram
Guinea pig
Intoxication
Intramuscular drug administration
Lethality
Nonhuman
Performance
Survival rate
Animal
Behavior, Animal
Chemical warfare agents
Cholinesterase inhibitors
Cholinesterase reactivators
Conditioning, Operant
Electroencephalography
Guinea pigs
Lethal dose 50
Pyridines
Pyridinium compounds
Respiratory mechanics
Animalia
Cavia
Cavia porcellus
Sus scrofa
Nutrition
Atropine, 51-55-8
HI 6, 34433-31-3
HLo 7, 120103-35-7
Phosphoric acid esters
Soman, 96-64-0
Tabun, 77-81-6
To reference this document use:
http://resolver.tudelft.nl/uuid:b7b6a2a8-4e08-4805-ad60-f4c75abb99d8
DOI
https://doi.org/10.1016/0091-3057(94)90223-2
TNO identifier
82282
ISSN
0091-3057
Source
Pharmacology, Biochemistry and Behaviour, 49 (49), 781-788
Document type
article