Title
Nanometric MIL-125-NH2 metal–organic framework as a potential nerve agent antidote carrier
Author
Vilela, S.M.F.
Salcedo-Abraira, P.
Colinet, I.
Salles, F.
de Koning, M.C.
Joosen, M.J.A.
Serre, C.
Horcajada, P.
Publication year
2017
Abstract
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH_2 (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and the release of drugs. The nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or pralidoxime) was effectively encapsulated into the pores of MIL-125-NH_2 as a result of the interactions between 2-PAM and the pore walls being mediated by π-stacking and hydrogen bonds, as deduced from infrared spectroscopy and Monte Carlo simulation studies. Finally, colloidal solutions of MIL-125-NH_2 nanoparticles exhibited remarkable stability in different organic media, aqueous solutions at different pH and under relevant physiological conditions over time (24 h). 2-PAM was rapidly released from the pores of MIL-125-NH_2 in vitro.
Subject
Observation, Weapon & Protection Systems
CBRN - CBRN Protection
TS - Technical Sciences
Chemistry
MIL-125-NH2
Metal–organic frameworks
Nanoparticles
Colloidal stability
Drug delivery
Pralidoxime
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http://resolver.tudelft.nl/uuid:b6595172-74bb-4652-b9bc-2781c15e293a
DOI
https://doi.org/10.3390/nano7100321
TNO identifier
781318
Source
Nanomaterials, 7 (10), 1-15
Article number
7100321
Document type
article