Analysis of activation markers off coagulation, fibrinolysis and inflammation in unstable angina by probit transformation
de Maat, M.P.M.
van der Greet, W.
Gaubius Instituut TNO
In order to investigate the role of the hemostatic, fibrinolytic and inflammatory system in unstable angina, we assessed the levels of thrombin-antithrombin III (TAT), Prothrombin Fragment 1+2 (F1+2), plasmin-antiplasmin (PAP) and D-Dimer (DD) and of C-reactive protein (CRP) in 51 patients admitted to our CCU with severe unstable angina. Thirty-one pts had a complicated in hospital course (G1), levels of CRP and PAP were significantly higher in this group than in patients with non complicated in-hospital course (G2). Using the probit transformation we assessed the following cut-off point between G1 and G2: 2.5 μg/1 for TAT, 0.9 nmol/ml for F1+2, 13 μg/l for DD, 500 μg/l for PAP, and 3.5 mg/l for CRP. Our study provides further evidence of the importance of markers of inflammation and fibrinolysis in unstable angina, and demonstrates the utility of data analysis by probit transformation. © Pearson Professional Ltd 1996.
To reference this document use:
C reactive protein
Plasmin antiplasmin complex
Thrombin antithrombin 3 complex
Major clinical study
Fibrinolysis, 10 (SUPPL. 2), 145-147