Print Email Facebook Twitter Twintig jaar coeliakie bij kinderen in Nederland: Meer diagnosen en een veranderde verschijningsvorm [Twenty years of childhood coeliac disease in the Netherlands: More diagnoses and changed clinical picture] Title Twintig jaar coeliakie bij kinderen in Nederland: Meer diagnosen en een veranderde verschijningsvorm [Twenty years of childhood coeliac disease in the Netherlands: More diagnoses and changed clinical picture] Author George, E.K. Mearin, M.L. Kanhai, Sh.M. Franken, H.C.M. Houwen, R.H.J. Hirasing, R.A. Vandenbroucke, J.P. TNO Preventie en Gezondheid Publication year 1998 Abstract Objective. To assess the incidence of childhood coeliac disease in the Netherlands and to study the clinical features. Design. Prospective. Setting. Leiden University Medical Centre, Leiden, the Netherlands. Method. Cases of childhood coeliac disease in the Netherlands in 1993-1995 were identified by means of the Dutch Paediatric Surveillance Unit. Inclusion criteria were: birth in the Netherlands, diagnosis with at least one small bowel biopsy in 1993-1995 and age at diagnosis 0-14 years. The data were cross checked with the Dutch Network and National Database of Pathology and compared with data from a previous study on childhood coeliac disease, 1975-1990. Results. 297 Coeliac patients were identified by means of the Surveillance Unit, another 32 through the National Database of Pathology. The mean crude incidence rate of diagnosed childhood coeliac disease was 0.15/1000 live births, which was in the range of rates found in other West European countries and significantly higher than the mean crude incidence rate of 0.18/1000 live births found in the Netherlands in 1975-1990. The clinical presentation was classic up to 1990: chronic diarrhoea, abdominal distention and growth failure. From 1993 onward, however, the number of children with chronic diarrhoea and abdominal distention decreased significantly and the number with weight loss, anaemia and abdominal pain increased. Associated disorders were present in 13.7% of the cases. Conclusions. The incidence of diagnosed childhood coeliac disease in the Netherlands showed a tendency to increase significantly during the past decade. In a period of 20 years a significant trend toward change in the clinical presentation of coeliac disease in Dutch children was observed. Subject HealthAdolescentCeliac DiseaseChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMaleNetherlandsProspective StudiesSex Distribution To reference this document use: http://resolver.tudelft.nl/uuid:b4485436-6639-4642-938a-feba51917fff TNO identifier 234433 ISSN 0028-2162 Source Nederlands Tijdschrift voor Geneeskunde, 142 (15), 850-854 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.