Title
Controlling false discovery rates in factorial experiments with between-subjects and within-subjects tests
Author
Schoen, E.D.
Rubingh, C.M.
Wopereis, S.
van Erk, M.
Publication year
2013
Abstract
Background: The False Discovery Rate (FDR) controls the expected number of false positives among the positive test results. It is not straightforward how to conduct a FDR controlling procedure in experiments with a factorial structure, while at the same time there are between-subjects and within-subjects factors. This is because there are P-values for different tests in one and the same response along with P-values for the same test and different responses. Findings: We propose a procedure resulting in a single P-value per response, calculated over the tests of all the factorial effects. FDR control can then be based on the set of single P-values. Conclusions: The proposed procedure is very easy to apply and is recommended for all designs with factors applied at different levels of the randomization, such as cross-over designs with added between-subjects factors.
Subject
Nutrition
Food and Nutrition
Healthy Living
Life
QS - Quality & Safety MSB - Microbiology and Systems Biology
EELS - Earth, Environmental and Life Sciences
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http://resolver.tudelft.nl/uuid:b2f3a7d3-f695-4906-814a-3ca4e738c793
TNO identifier
473796
Source
BMC Research Notes, 6 (6)
Document type
article