Print Email Facebook Twitter Nuclear factor-kB activation is higher in peripheral blood mononuclear cells of male smokers Title Nuclear factor-kB activation is higher in peripheral blood mononuclear cells of male smokers Author van den Berg, R. Haenen, G.R.M.M. van den Berg, H. Bast, A. Instituut CIVO-Toxicologie en Voeding TNO Publication year 2001 Abstract Nuclear factor-κB (NF-κB) is an oxidative stress sensitive transcription factor involved in the regulation of inflammatory genes. Activation of NF-κB results into increased expression of inflammatory genes such as for interleukins, endothelial cell leukocyte adhesion molecules and inducible NO synthase. Our study, with six smokers and 10 non-smokers, showed that NF-κB activity in peripheral blood mononuclear cells of smokers compared to non-smokers is significantly higher (P < 0.05). This indicates that NF-κB is involved in cigarette smoke induced inflammatory responses and that NF-κB activation can be used as a functional marker of oxidative stress. © 2001 Elsevier Science B.V. Subject EnvironmentCigarette smokeInflammationNF-κBOxidative stress To reference this document use: http://resolver.tudelft.nl/uuid:b2461494-b013-4281-b3b1-290773bc534f DOI https://doi.org/10.1016/s1382-6689(00)00070-3 TNO identifier 72248 ISSN 1382-6689 Source Environmental Toxicology and Pharmacology, 9 (4), 147-151 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.