Print Email Facebook Twitter Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels: A randomized, diet-controlled intervention study Title Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels: A randomized, diet-controlled intervention study Author Sierksma, A. van der Gaag, M.S. Kluft, C. Hendriks, H.F.J. TNO Voeding Publication year 2002 Abstract Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully. Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects. Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P = 0.02) and 12.4% (P ≤ 0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption. Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk. Subject NutritionAlcoholAtherosclerosisC-reactive proteinFibrinogenInflammationAcetylsalicylic acidAcute phase proteinAlanine aminotransferaseAspartate aminotransferaseEstradiolFollitropinGamma glutamyltransferaseGlucoseHemoglobinHigh density lipoprotein cholesterolLow density lipoprotein cholesterolParacetamolTriacylglycerolAdultAlcohol consumptionAntiinflammatory activityCardiovascular riskCigarette smokingClinical trialControlled clinical trialControlled studyCrossover procedureDiet therapyFibrinogen blood levelFood compositionHuman experimentNetherlandsPostmenopauseProtein blood levelRandomized controlled trialAlcohol DrinkingBeerC-Reactive ProteinCardiovascular DiseasesCholesterol, HDLCross-Over StudiesDietFemaleHumansLiverMaleMiddle AgedPostmenopauseTriglycerides To reference this document use: http://resolver.tudelft.nl/uuid:b1b9fbb7-c11f-48b1-ae1a-7ff0cf2319e0 DOI https://doi.org/10.1038/sj.ejcn.1601459 TNO identifier 87748 Source European Journal of Clinical Nutrition, 56 (11), 1130-1136 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.