Title
Recent advances using rodent models for predicting human allergenicity
Author
TNO Kwaliteit van Leven
Knippels, L.M.J.
Penninks, A.H.
Publication year
2005
Abstract
The potential allergenicity of newly introduced proteins in genetically engineered foods has become an important safety evaluation issue. However, to evaluate the potential allergenicity and the potency of new proteins in our food, there are still no widely accepted and reliable test systems. The best-known allergy assessment proposal for foods derived from genetically engineered plants was the careful stepwise process presented in the so-called ILSI/IFBC decision tree. A revision of this decision tree strategy was proposed by a FAO/WHO expert consultation. As prediction of the sensitizing potential of the novel introduced protein based on animal testing was considered to be very important, animal models were introduced as one of the new test items, despite the fact that non of the currently studied models has been widely accepted and validated yet. In this paper, recent results are summarized of promising models developed in rat and mouse. © 2005 Elsevier Inc. All rights reserved. Chemicals / CAS: egg white, 9006-50-2; immunoglobulin G, 97794-27-9; ovalbumin, 77466-29-6; Allergens; Immunoglobulin E, 37341-29-0; Immunoglobulin G.
Subject
Toxicology and Applied Pharmacology
Allergenicity
Animal models
Food allergy
albuminoid
egg white
food allergen
immunoglobulin G
immunological adjuvant
ovalbumin
vegetable protein
conference paper
DNA modification
experimental model
food industry
genetic engineering
genetically modified food
milk
mouse strain
nonhuman
plant genetics
provocation test
rat strain
sensitization
validation process
world health organization
Administration, Oral
Allergens
Animals
Dose-Response Relationship, Immunologic
Humans
Immunoglobulin E
Immunoglobulin G
Mice
Mice, Inbred BALB C
Models, Animal
Rats
Animalia
Rodentia
To reference this document use:
http://resolver.tudelft.nl/uuid:b00a198a-ac17-47e7-9242-4fe6577b4a95
DOI
https://doi.org/10.1016/j.taap.2005.01.031
TNO identifier
238671
ISSN
0041-008X
Source
Toxicology and Applied Pharmacology, 207 (207), 157-160
Document type
article