Hemodynamic effects of intermittent manual lung heperinflation in patients with septic shock
TNO Biomedical Instrumentation
van Goudoever, J.
van Lieshout, J.J.
OBJECTIVE: The purposes of this study were to investigate the hemodynamic changes induced by intermittent manual lung hyperinflation (MHI) and to assess if these changes are adverse enough to warrant prohibition of MHI as a routine procedure in the care of patients with septic shock. DESIGN: The study's design was experimental prospective. SETTING: The settings were university hospital intensive care units. PATIENTS: Subjects included 13 consecutive mechanically ventilated patients with septic shock who met the inclusion criteria. MEASUREMENTS AND RESULTS: Phasic MHI-related increments in mean inspiratory airway pressure were concordant to changes in mean pulmonary artery pressure (MPAP) (r2 = 0.67) with a 0.6 mm Hg rise in MPAP per cm H2O airway pressure. The magnitude of MPAP changes was not reflected in magnitude of stroke volume index (SVI) (r2 = 0.06). On average, MHI did not induce statistically significant hemodynamic changes and mean values returned to baseline level within 15 minutes. SVI during MHI increased slightly in 9 patients, from 37 ± 15 (mean ± SD) to 41 ± 17 mL/m2 (P
To reference this document use:
Aged BArtificial ventilation
Heart left ventricle function
Intermittent manual lung hyperinflation
Support, Non-U.S. Gov't
Ventricular Function, Left
Heart and Lung: Journal of Acute and Critical Care, 29 (29), 356-366