Print Email Facebook Twitter Using chemical categories to fill data gaps in hazard assessment. Title Using chemical categories to fill data gaps in hazard assessment. Author van Leeuwen, K. Schultz, T.W. Henry, T. Diderich, B. Veith, G.D. TNO Kwaliteit van Leven Publication year 2009 Abstract Hazard assessments of chemicals have been limited by the availability of test data and the time needed to evaluate the test data. While available data may be inadequate for the majority of industrial chemicals, the body of existing knowledge for most hazards is large enough to permit reliable estimates to be made for untested chemicals without additional animal testing. We provide a summary of the growing use by regulatory agencies of the chemical categories approach, which groups chemicals based on their similar toxicological behaviour and fills in the data gaps in animal test data such as genotoxicity and aquatic toxicity. Although the categories approach may be distinguished from the use of quantitative structure-activity relationships (QSARs) for specific hazard endpoints, robust chemical categories are founded on quantifying the chemical structure with parameters that control chemical behaviour in conventional hazard assessment. The dissemination of the QSAR Application Toolbox by the Organisation for Economic Cooperation and Development (OECD) is an effort to facilitate the use of the categories approach and reduce the need for additional animal testing. Subject ChemistryFood and Chemical Risk Analysisdangerous goodsmethodologyquantitative structure activity relationreviewsafetyHazardous SubstancesQuantitative Structure-Activity RelationshipSafety Management To reference this document use: http://resolver.tudelft.nl/uuid:af6ba91c-f320-4389-951a-649930b4a733 TNO identifier 241685 ISSN 1029-046X Source SAR and QSAR in environmental research, 20 (3-4), 207-220 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.