Title
Adverse effects of Formamid and N,N-Dimethylformamid on fertility and reproduction
Author
Instituut CIVO-Toxicologie en Voeding TNO
Koëter, H.B.W.M.
Blijleven, W.G.H.
Dreef-van der Meulen, H.C.
Stijkel, A.
Zielhuis, R.L.
Publication year
1989
Abstract
It is concludes on the basis of animal studies that formamide is highly embryolethal and teratogenic. N,N-dimethylformamide is probably embryolethal but not teratogenic. Although at least in one study (Keller and Lewis, 1981) it was concluded that the current MAC of 10 ppm gives adequate protection, effects on reproductive parameters have also been observed at dose levels that are loss less than 10% of the current MAC-value (30 mg/m3 = 10 ppm). It is further emphasized that human data with respect to the risks of formamide and N,N-dimethylformamide are inadequate to confirm the findings in animals. It is concluded that additional studies in animals are necessary.
Subject
Historisch materiaal TNO
Voortplanting
Vruchtbaarheid
Onvruchtbaarheid
Teratogenese
Proefdieren
Epidemiologie
MAC
Maximaal aanvaarde concentratie
Formamide
Dimethylformamide
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http://resolver.tudelft.nl/uuid:aea9654c-8f31-4a9d-9ba3-54d88aa4c29d
TNO identifier
160925
Report number
Ser. 4, S 73-8
Publisher
Min. SZW, Arbeidsinspectie ; DGA, Den Haag
ISBN
9053070125
ISSN
0921-9218
Series
Studie
Document type
book