Title
Dietary folate and folate vitamers and the risk of pancreatic cancer in the Netherlands cohort study
Author
Keszei, A.P.
Verhage, B.A.J.
Heinen, M.M.
Goldbohm, R.A.
van den Brandt, P.A.
TNO Kwaliteit van Leven
Publication year
2009
Abstract
An association between high intake of folate and reduced risk of cancer has been suggested by previous research. However, epidemiologic data from cohort studies regarding the relationship between dietary folate and pancreatic cancer are sparse and inconsistent. We examined the association between dietary folate intake and risk of pancreatic cancer within the Netherlands Cohort Study on diet and cancer. Men and women (120,852), ages 55 to 69 years, were recruited. Information on diet was collected at baseline by means of food frequency questionnaires, and the cohort was followed for 13.3 years. Total folate and vitamer intake were calculated using folate contents of food items derived from a validated liquid chromatography trienzyme method. Cases (n = 363) were identified by record linkage with regional cancer registries and the Dutch National Database of Pathology Reports. A casecohort approach was used using the follow-up data of a random subcohort (n = 5,000) identified at the onset of the cohort. Multivariable hazard ratios with 95% confidence intervals were estimated using Cox proportional hazards model. After adjusting for age, gender, smoking status, number of years smoked, number of cigarettes smoked per day, and intake of added sugar multivariate hazard ratio comparing the highest and lowest quintiles of folate intake for pancreatic cancer risk was 1.37 (confidence interval, 0.97-1.94; Ptrend = 0.07). When folate vitamers were analyzed separately, results did not show a difference in association. Our results do not support a protective association of total dietary folate or individual folate vitamers on the risk of pancreatic cancer. Copyright © 2009 American Association for Cancer Research.
Subject
Health
Leefomgeving en gezondheid
Cancer incidence
Cancer risk
Dietary intake
Aged
Cohort Studies
Diet
Dietary Supplements
Female
Folic Acid
Humans
Incidence
Male
Middle Aged
Netherlands
Pancreatic Neoplasms
Questionnaires
Risk Factors
Vitamin B Complex
To reference this document use:
http://resolver.tudelft.nl/uuid:aea74aaa-e2cf-4ec2-91d5-12f3280abef4
DOI
https://doi.org/10.1158/1055-9965.epi-08-1220
TNO identifier
241552
ISSN
1055-9965
Source
Cancer Epidemiology Biomarkers and Prevention, 18 (6), 1785-1791
Document type
article