Title
Prostate cancer susceptibility genes on 8P21-23 in a Dutch population
Author
Zeegers, M.P.
Nekeman, D.
Khan, H.S.
van Dijk, B.A.C.
Goldbohm, R.A.
Schalken, J.
Shajahan, S.
Pearlman, A.
Oddoux, C.
van den Brandt, P.A.
Schouten, L.J.
Ostrer, H.
TNO Preventie en Gezondheid
Publication year
2013
Abstract
Background:Prostate cancer is the most commonly diagnosed cancer in men in Europe and the United States. Numerous studies have indicated genetics to have a major role in the aetiology of this disease; as much as 42% of the risk may be explained by heritable factors. Genome-wide association studies have detected an association between prostate cancer and chromosome 8p21-23. In this study, we analysed eight microsatellite (MS) markers in that region in order to confirm previous results and narrow down the location of candidate prostate cancer genes.Methods:292 cases and 278 controls were selected from the Netherlands Cohort Study (NLCS). The following MSs were used in the analyses: D8S136, D8S1734, D8S1742, D8S261, D8S262, D8S351, D8S511 and D8S520. Associations were evaluated using a χ 2 test and logistic regression. We checked for any effects on the association by tumour stage.Results:Associations that were found confirmed previous research that pointed to the 8p21-23 region. Two MSs: D8S136 (odds ratio (OR), 0.69; P=4.00 × 10 -28), and D8S520 (OR, 0.80; P=3.37 × 10 -11), were consistently and strongly related with prostate cancer. Genotype analysis showed an additive effect for D8S136 (P-trend=6.22 × 10 -03) and D8S520 (P-trend=2.62 × 10 -22), suggesting an increased risk for people with a short number of repeats on both alleles at those markers.Conclusions:This study provides strong evidence that the 8p21-23 region is likely to harbour prostate cancer genes.© 2013 Macmillan Publishers Limited All rights reserved. Chemicals/CAS: lipoprotein lipase, 83137-80-8, 9004-02-8
Subject
Human
LS - Life Style
BSS - Behavioural and Societal Sciences
Healthy for Life
Health
Healthy Living
Epidemiology
Microsatellite repeats/genetics
Prostatic neoplasm/genetics
Lipoprotein lipase
Adult
Advanced cancer
Aged
Allele
Animal tissue
Cancer risk
Cancer staging
Chromosome 8p21
Chromosome 8p22
Chromosome 8p23
Controlled study
disease association
Genetic association
Genotype
Human
LPL gene
Major clinical study
Male
Microsatellite marker
Msr1 gene
MTSG1 gene
NKX3.1 gene
Nonhuman
Polymerase chain reaction
Prostate cancer
Tumor gene
To reference this document use:
http://resolver.tudelft.nl/uuid:aaffc1bc-4a44-41d4-a86e-4dce74e5cb76
DOI
https://doi.org/10.1038/pcan.2013.9
TNO identifier
478827
ISSN
1365-7852
Source
Prostate Cancer and Prostatic Diseases, 16 (3), 248-253
Document type
article