Print Email Facebook Twitter Occupational extremely low-frequency magnetic field exposure and selected cancer outcomes in a prospective Dutch cohort Title Occupational extremely low-frequency magnetic field exposure and selected cancer outcomes in a prospective Dutch cohort Author Koeman, T. van den Brandt, P.A. Slottje, P. Schouten, L.J. Goldbohm, R.A. Kromhout, H. Vermeulen, R. Publication year 2014 Abstract Purpose: To investigate the association between exposure to occupational extremely low-frequency magnetic fields (ELF-MF) and the risk of a priori selected cancer outcomes within the prospective Netherlands Cohort Study. Methods: 120,852 men and women aged 55-69 years at time of enrollment in 1986 were followed up (17.3 years) for incident lung, breast and brain cancer, and hemato-lymphoproliferative malignancies. Information on occupational history and potential confounders such as sex, age, smoking, alcohol use, and attained educational level were collected at baseline through a self-administered questionnaire. Occupational ELF-MF exposure was assigned with a job-exposure matrix. Using a case-cohort approach, associations with cancer incidence were analyzed with Cox regression stratified by sex, using three exposure metrics: (1) ever had a job with low or high exposure to ELF-MF versus background, (2) duration of exposure, and (3) cumulative exposure. Results: None of the exposure metrics showed an effect on incidence for lung, breast, and brain cancer, nor any of the assessed subtypes in men and women. Of the hemato-lymphoproliferative malignancies in men, ever high exposed to ELF-MF showed a significant association with acute myeloid leukemia (AML) [hazard ratio (HR) 2.15; 95 % confidence interval (CI) 1.06-4.35] and follicular lymphoma (FL) (HR 2.78; 95 % CI 1.00-5.77). Cumulative exposure to ELF-MF showed a significant, positive association with FL but not AML among men. Conclusions: In this large prospective cohort study, we found some indications of an increased risk of AML and FL among men with occupational ELF-MF exposure. These findings warrant further investigation. © 2013 Springer Science+Business Media Dordrecht. Subject Behavioural ChangesLS - Life StyleELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingBrain cancerBreast cancerExtremely low-frequency magnetic fieldsLeukemiaLung cancerNon-Hodgkin lymphomaProspective cohort To reference this document use: http://resolver.tudelft.nl/uuid:a8f9440a-9433-4220-aba1-0ac098cc70c1 DOI https://doi.org/10.1007/s10552-013-0322-x TNO identifier 489140 ISSN 0957-5243 Source Cancer Causes and Control, 25 (2), 203-214 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.