Print Email Facebook Twitter Fasting ghrelin does not predict food intake after short-term energy restriction Title Fasting ghrelin does not predict food intake after short-term energy restriction Author Blom, W.A.M. Mars, M. Hendriks, H.F.J. de Groot, L.C.P.G.M. Stafleu, A. Kok, F.J. de Graaf, C. TNO Kwaliteit van Leven Publication year 2006 Abstract Objective: To study the role of ghrelin as a hunger signal during energy restriction and to test the hypothesis that changes in fasting leptin concentrations during energy restriction are associated with changes in fasting ghrelin concentrations. Research Methods and Procedures: Thirty-five healthy, lean men (23 ± 3 years of age; BMI: 22.3 ±1.6 kg/m2) participated in a controlled intervention study. Fasting ghrelin and leptin concentrations were measured before and after 2 days of 62% energy restriction and after a 2-day period of ad libitum food intake. Energy intake during the latter period was assessed. Results: On average, ghrelin concentrations did not change (0.05 μg/liter; 95% confidence interval, -0.03; 0.12) during energy restriction. Changes in ghrelin concentration during energy restriction were not associated with energy intake during the ad libitum period (r = 0.07; not significant). Ad libitum energy intake was, however, associated with the change in ghrelin concentrations during the same period (r = -0.34; p = 0.05). Ghrelin and leptin concentrations were not associated. In addition, the ratio of percentage changes in ghrelin and leptin during energy restriction was not correlated with ad libitum food intake after energy restriction (r = -0.26; p = 0.14). Discussion: Fasting ghrelin concentrations did not rise after a 2-day energy restriction regimen. Moreover, changes in ghrelin concentrations during energy restriction were not associated with subsequent ad libitum food intake, suggesting that fasting ghrelin does not act as a hunger signal to the brain. The data did not support our hypothesis that leptin suppresses ghrelin levels. Copyright © 2006 NAASO. Subject NutritionBiomedical ResearchEnergy intakeEnergy restrictionHungerLeptinMenghrelinpeptide hormoneadolescentadultarticlebloodcaloric intakecaloric restrictionclinical trialcontrolled clinical trialcontrolled studydiet restrictioneatingfeeding behaviorhumanmalemiddle agedphysiologyprediction and forecastingtimeAdolescentAdultCaloric RestrictionEatingEnergy IntakeFastingFeeding BehaviorHumansMaleMiddle AgedPeptide HormonesPredictive Value of TestsTime Factors To reference this document use: http://resolver.tudelft.nl/uuid:a86eb77d-43da-42ba-8f89-37e075c7ce52 DOI https://doi.org/10.1038/oby.2006.97 TNO identifier 239262 ISSN 1930-7381 Source Obesity, 14 (5), 838-846 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.