Title
Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity
Author
Olga, L.
van Diepen, J.A.
Bobeldijk-Pastorova, I.
Gross, G.
Prentice, S.M.
Snowden, S.G.
Furse, S.
Kooistra, T.
Hughes, I.A.
Schoemaker, M.H.
van Tol, E.A.F.
van Duyvenvoorde, W.
Wielinga, P.Y.
Ong, K.K.
Dunger, D.B.
Kleemann, R.
Koulman, A.
Publication year
2021
Abstract
Background: Altered lipid metabolism in early life has been associated with subsequent weight gain and predicting this could aid in obesity prevention and risk management. Here, a lipidomic approach was used to identify circulating markers for future obesity risk in translational murine models and validate in a human infant cohort. Methods: Lipidomics was performed on the plasma of APOE*3 Leiden, Ldlr-/-.Leiden, and the wild-type C57BL/6J mice to capture candidate biomarkers predicting subsequent obesity parameters after exposure to high-fat diet. The identified candidate biomarkers were mapped onto corresponding lipid metabolism pathways and were investigated in the Cambridge Baby Growth Study. Infants' growth and adiposity were measured at 0-24 months. Capillary dried blood spots were sampled at 3 months for lipid profiling analysis. Findings: From the mouse models, cholesteryl esters were correlated with subsequent weight gain and other obesity parameters after HFD period (Spearman's r≥0.5, FDR p values
Subject
Adiposity
Desaturase
FADS
Infant growth
Lipid ratio
SCD1
To reference this document use:
http://resolver.tudelft.nl/uuid:a81f519a-9407-42e2-a290-d31790836dca
DOI
https://doi.org/10.1016/j.ebiom.2020.103198
TNO identifier
946483
Source
EBioMedicine, 63 (63)
Document type
article