Print Email Facebook Twitter The development of clinical activity in relapsing-remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood Title The development of clinical activity in relapsing-remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood Author Lopatinskaya, L. Boxel van-Dezaire, A.H.H. Barkhof, F. Polman, C.H. Lucas, C.J. Nagelkerken, L. Publication year 2003 Abstract In this longitudinal study, we examined the expression of Fas, FasL, CCR3, CCR5 and CXCR3 mRNA in peripheral blood mononuclear cells (PBMCs) of secondary progressive (SP) and relapsing-remitting (RR) multiple sclerosis (MS) patients. In RR patients, FasL, CCR3 and CCR5 mRNA levels were increased prior to the exacerbations, but these decreased during clinical activity, while mRNA levels of Fas increased. SP patients have increased the levels of Fas and FasL mRNA; the latter was particularly increased during lesional activity. Our data support the hypothesis that changes in Fas and FasL mRNA related to clinical activity are due to the migration of inflammatory cells to the central nervous system (CNS). © 2003 Elsevier Science B.V. All rights reserved. Chemicals/CAS: Antigens, CD95; CC chemokine receptor 3; CXC chemokine receptor 3; Fas Ligand Protein; FASLG protein, human; Ligands; Membrane Glycoproteins; Receptors, CCR5; Receptors, Chemokine; RNA, Messenger Subject HealthCCR3CCR5CXCR3Fas (Apo-1, CD95)Fas Ligand (CD95L, CD178)Chemokine receptor CCR3Chemokine receptor CCR5Chemokine receptor CXCR3Fas antigenFAS ligandMessenger RNABloodCell migrationCentral nervous systemClinical articleControlled studyDisease activityDisease exacerbationInflammatory cellMononuclear cellMultiple sclerosisProtein expressionAdultAntigens, CD95ApoptosisCross-Sectional StudiesDown-RegulationFas Ligand ProteinHumansLigandsLongitudinal StudiesMembrane GlycoproteinsMiddle AgedMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingReceptors, CCR5Receptors, ChemokineRNA, MessengerUp-Regulation To reference this document use: http://resolver.tudelft.nl/uuid:a7dc66b4-c46d-4c5b-b819-0f6cd082552d DOI https://doi.org/10.1016/s0165-5728(03)00089-4 TNO identifier 237074 ISSN 0165-5728 Source Journal of Neuroimmunology, 138 (1-2), 123-131 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.