Title
A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
Author
Kepner, L.A.
Wolthuis, O.L.
Medisch Biologisch Laboratorium TNO
Publication year
1978
Abstract
The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen following HI-6. In anesthetized atropinized rats, the administration of HI-6 resulted in a longer duration of spontaneous breathing and a higher degree of recovery of neuromuscular function than did the use of HS-6. HS-6 interacted with soman to alter the rate of excretion of the oxime. This problem was not encountered when HI-6 was used. Chemicals/CAS: atropine, 51-55-8, 55-48-1; soman, 96-64-0; Atropine, 51-55-8; Organophosphorus Compounds; Oximes; Soman, 96-64-0
Subject
Biology
Atropine
Cholinesterase reactivator
Oxime
Soman
1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether
Animal experiment
Breathing
Drug comparison
Drug intoxication
Drug response
Intoxication
Intraperitoneal drug administration
Mouse
Muscle
Musculoskeletal system
Neuromuscular transmission
Organophosphate poisoning
Rat
Respiratory system
Subcutaneous drug administration
Animal
Atropine
Comparative Study
Drug Synergism
Female
Male
Mice
Neuromuscular Junction
Organophosphorus Compounds
Oximes
Rats
Rats, Inbred Strains
Respiration
Soman
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TNO identifier
228407
ISSN
0014-2999
Source
European Journal of Pharmacology, 48 (4), 377-382
Document type
article