Print Email Facebook Twitter A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents Title A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents Author Kepner, L.A. Wolthuis, O.L. Medisch Biologisch Laboratorium TNO Publication year 1978 Abstract The bisquaternary mono-oximes HS-6 and HI-6 may both be considered as potential therapeutic agents for soman intoxication. It has been found that HI-6 was superior to an equal dose of HS-6 in the treatment of soman intoxication in mice and rats. Not only did HI-6 protect against higher levels of soman, but also fewer 'delayed deaths' were seen following HI-6. In anesthetized atropinized rats, the administration of HI-6 resulted in a longer duration of spontaneous breathing and a higher degree of recovery of neuromuscular function than did the use of HS-6. HS-6 interacted with soman to alter the rate of excretion of the oxime. This problem was not encountered when HI-6 was used. Chemicals/CAS: atropine, 51-55-8, 55-48-1; soman, 96-64-0; Atropine, 51-55-8; Organophosphorus Compounds; Oximes; Soman, 96-64-0 Subject BiologyAtropineCholinesterase reactivatorOximeSoman1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl etherAnimal experimentBreathingDrug comparisonDrug intoxicationDrug responseIntoxicationIntraperitoneal drug administrationMouseMuscleMusculoskeletal systemNeuromuscular transmissionOrganophosphate poisoningRatRespiratory systemSubcutaneous drug administrationAnimalAtropineComparative StudyDrug SynergismFemaleMaleMiceNeuromuscular JunctionOrganophosphorus CompoundsOximesRatsRats, Inbred StrainsRespirationSoman To reference this document use: http://resolver.tudelft.nl/uuid:a5bb25e6-4874-4204-ad32-d8628488dd54 TNO identifier 228407 ISSN 0014-2999 Source European Journal of Pharmacology, 48 (4), 377-382 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.