Title
The case for strategic international alliances to harness nutritional genomics for public and personal health
Author
TNO Kwaliteit van Leven
Kaput, J.
Ordovas, J.M.
Ferguson, L.
van Ommen, B.
Rodriguez, R.L.
Allen, L.
Ames, B.N.
Dawson, K.
German, B.
Krauss, R.
Malyj, W.
Archer, M.C.
Barnes, S.
Bortholomew, A.
Birk, R.
van Bladeren, P.
Bradford, K.J.
Brown, K.H.
Caetano, R.
Castle, D.
Chadwick, R.
Clarke, S.
Clemént, K.
Cooney, C.A.
Corella, D.
da Cruz, I.B.M.
Daniel, H.
Duster, T.
Ebbesson, S.O.E.
Elliott, R.
Fairweather-Tait, S.
Felton, J.
Fenech, M.
Finley, J.W.
Fogg-Johnson, N.
Gill-Garrison, R.
Gibney, M.J.
Gillies, P.J.
Gustafsson, J.A.
Hartman IV, J.L.
He, L.
Hwang, J.K.
Jais, J.P.
Jang, Y.
Joost, H.
Junien, C.
Kanter, M.
Kibbe, W.A.
Koletzko, B.
Korf, B.R.
Kornman, K.
Krempin, D.W.
Langin, D.
Lauren, D.R.
Lee, J.H.
Leveille, G.A.
Lin, S.J.
Mathers, J.
Mayne, M.
McNabb, W.
Milner, J.A.
Morgan, P.
Muller, M.
Nikolsky, Y.
van der Ouderaa, F.
Park, T.
Pensel, N.
Perez-Jimenez, F.
Poutanen, K.
Roberts, M.
Saris, W.H.M.
Schuster, G.
Shelling, A.N.
Simopoulos, A.P.
Southon, S.
Shyong Tai, E.
Towne, B.
Trayhurn, P.
Uauy, R.
Visek, W.J.
Warden, C.
Weiss, R.
Wiencke, J.
Winkler, J.
Wolff, G.L.
Zhao-Wilson, X.
Zucker, J.D.
Publication year
2005
Abstract
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries. © The Authors 2005.
Subject
Biomedical Research
Gene-nutrient interactions
Health diaparities
Nutrigenomics
Strategic international alliances
article
cultural factor
dietary intake
environmental factor
gene identification
genetic variability
genotype
heredity
human
medical research
molecular genetics
nonhuman
nutrigenomics
nutritional health
phenotype
population genetics
public health service
Animals
Disease Models, Animal
Eating
Environment
Genome, Human
Genomics
Humans
International Cooperation
Nutrition Physiology
Phenotype
Research
Variation (Genetics)
Harness
To reference this document use:
http://resolver.tudelft.nl/uuid:a59ae1c4-51d0-4efa-accf-aa391b589b37
DOI
https://doi.org/10.1079/bjn20051585
TNO identifier
238789
ISSN
0007-1145
Source
British Journal of Nutrition, 94 (94), 623-632
Document type
article