Print Email Facebook Twitter The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: A randomized, controlled trial Title The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: A randomized, controlled trial Author van Uffelen, J.G.Z. Chin A Paw, M.J.M. Hopman-Rock, M. van Mechelen, W. TNO Kwaliteit van Leven Publication year 2007 Abstract Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment. Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL. Results: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08). Conclusion: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed. Trial Registration: International Standard Randomized Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/. © 2007 Springer Science+Business Media B.V. Subject Leefomgeving en gezondheidAgedDietary supplementsExerciseQuality of lifeRandomized controlled trialcyanocobalaminfolic acidplacebopyridoxinevitamin B groupagedarticleclinical trialcognitive defectcommunitycontrolled clinical trialcontrolled studyDementia Quality of Lifedisease severitydouble blind proceduredrug effectexercisefemalehumanmajor clinical studymalepatient compliancepriority journalquality of lifequestionnairerandomized controlled trialShort Form 12vitamin supplementationwalkingAgedAged, 80 and overCognitionCognition DisordersCommunity Health ServicesDementiaDietary SupplementsFemaleHealth SurveysHumansInterviewsMaleNeuropsychological TestsNutritional StatusProgram EvaluationPsychometricsQuality of LifeQuestionnairesResidence CharacteristicsTreatment OutcomeVitamin B ComplexWalking To reference this document use: http://resolver.tudelft.nl/uuid:a56d08dc-0c20-43d3-8212-03e0302e58ae DOI https://doi.org/10.1007/s11136-007-9219-z TNO identifier 240178 Publisher Springer ISSN 0962-9343 Source Quality of Life Research, 16 (7), 1137-1146 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.