Print Email Facebook Twitter Reference chart for relative weight change to detect hypernatraemic dehydration Title Reference chart for relative weight change to detect hypernatraemic dehydration Author van Dommelen, P. van Wouwe, J.P. Breuning-Boers, J.M. van Buuren, S. Verkerk, P.H. TNO Kwaliteit van Leven Publication year 2007 Abstract Objective: The validity of the rule of thumb that infants may have a weight loss of 10% in the first days after birth is unknown. We assessed the validity of this and other rules to detect breast-fed infants with hypernatraemic dehydration. Design: A reference chart for relative weight change was constructed by the LMS method. The reference group was obtained by a retrospective cohort study. Participants: 1544 healthy, exclusively breast-fed infants with 3075 weight measurements born in the Netherlands and 83 cases of breast-fed infants with hypernatraemic dehydration obtained from literature. Results: The rule of thumb had a sensitivity of 90.4%, a specificity of 98.3% and a positive predictive value of 3.7%. Referring infants if their weight change is below -2.5 SDS (0.6th centile) in the reference chart in the first week of life and using the rule of thumb in the second week had a sensitivity of 85.5%, a specificity of 99.4% and a positive predictive value of 9.2%. Conclusions: The rule of thumb is likely to produce too many false positive results, assuming that for screening purposes the specificity needs to be high. A chart for relative weight change can be helpful to detect infants with hypernatraemic dehydration. Subject Jeugd en Gezondheidsodiumarticlebirth weightbreast feedingclinical featurecontrolled studydehydrationdemographyfemalehumanhypernatremiainfantmajor clinical studymalepriority journalsensitivity and specificitysodium blood levelweight changeweight reductionBreast FeedingDehydrationEpidemiologic MethodsEvidence-Based MedicineFemaleHumansHypernatremiaInfant CareInfant, NewbornMaleNetherlandsReference ValuesReferral and ConsultationWeight Loss To reference this document use: http://resolver.tudelft.nl/uuid:a4054fa4-6a5f-4b32-b2d5-d9c6ab702e0e DOI https://doi.org/10.1136/adc.2006.104331 TNO identifier 239992 ISSN 0003-9888 Source Archives of Disease in Childhood, 92 (6), 490-494 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.