Vitamin A intervention: Short-term effects of a single, oral, massive dose on iron metabolism
van Agtmaal, E.J.
Centraal Instituut voor Voedingsonderzoek TNO
A group of 134 school children aged 3-9 y, with signs of conjunctival xerosis, from the rural area of Sakorn Nakhon province of Northeast Thailand were selected for a controlled study on the short-term effect (2 wk) of a single, oral high dose of vitamin A on iron metabolism. After collection of the baseline data, children within villages were randomly assigned to receive the capsules (n = 65) or serve as control subjects (n = 69). Two weeks after supplementation significant increases of retinol, retinol-binding protein, hemoglobin, hematocrit, serum iron, and saturation of transferrin were found in the supplemented group. Ferritin concentrations did not change significantly. These short-term changes completely exclude seasonal effects and change in morbidity. This study provides evidence of a causal association between vitamin A and iron metabolism. In areas where vitamin A deficiency is endemic, periodic massive vitamin A dose programs can also improve iron status of the population.
To reference this document use:
Vitamin A supplementation
Vitamin A-iron interaction
Oral drug administration
Dose-Response Relationship, Drug
Support, Non-U.S. Gov't
Vitamin A Deficiency
American Journal of Clinical Nutrition, 51 (1), 76-79