Title
Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke
Author
de Lau, L.M.L.
Cheung, E.Y.L.
Kluft, C.
Leebeek, F.W.G.
Meijer, P.
Laterveer, R.
Dippel, D.W.J.
de Maat, M.P.M.
TNO Kwaliteit van Leven
Publication year
2008
Abstract
Ischemic stroke is associated with leucocyte activation. Activated leucocytes release elastase, an enzyme that can degrade fibrinogen. Fibrinogen elastase degradation products (FgEDP) may serve as a specific marker of elastase proteolytic activity. In a case-control study of 111 ischemic stroke patients and 119 controls, significantly higher FgEDP levels were observed in cases than in controls, both in the acute phase and in the convalescent phase. Results were only slightly affected by adjustment for cardiovascular risk factors, C-reactive protein and fibrinogen. Our findings suggest that FgEDP might be involved in the pathogenesis of stroke. © 2008 The Authors.
Subject
Biology
Biomedical Research
Elastase
Epidemiology
Fibrinogen degradation products
Leucocyte activation
Stroke
C reactive protein
elastase
fibrinogen
adult
article
cardiovascular risk
cerebrovascular accident
controlled study
convalescence
disease course
female
fibrinogen blood level
human
major clinical study
male
priority journal
protein degradation
stroke patient
Adult
Aged
Biological Markers
C-Reactive Protein
Case-Control Studies
Female
Fibrin Fibrinogen Degradation Products
Fibrinogen
Humans
Ischemic Attack, Transient
Lymphocyte Activation
Male
Middle Aged
Odds Ratio
Pancreatic Elastase
Risk
Stroke
To reference this document use:
http://resolver.tudelft.nl/uuid:9f82f039-53a1-4bd2-a2ca-5749d8ef378f
DOI
https://doi.org/10.1111/j.1365-2141.2008.07395.x
TNO identifier
241226
ISSN
0007-1048
Source
British Journal of Haematology, 143 (5), 734-737
Document type
article