Title
The Network Library: A framework to rapidly integrate network biology resources
Author
Summer, G.
Kelder, T.
Radonjic, M.
van Bilsen, M.
Wopereis, S.
Heymans, S.
Publication year
2016
Abstract
Motivation: Much of the biological knowledge accumulated over the last decades is stored in different databases governed by various organizations and institutes. Integrating and connecting these vast knowledge repositories is an extremely useful method to support life sciences research and help formulate novel hypotheses. Results: We developed the Network Library (NL), a framework and toolset to rapidly integrate different knowledge sources to build a network biology resource that matches a specific research question. As a use-case we explore the interactions of genes related to heart failure with miRNAs and diseases through the integration of 6 databases. Availability and Implementation: The NL is open-source, developed in Java and available on Github (https://github.com/gsummer). © 2016 The Author 2016. Published by Oxford University Press. All rights reserved.
Subject
Life
MSB - Microbiology and Systems Biology
ELSS - Earth, Life and Social Sciences
Biomedical Innovation
Biology
Healthy Living
To reference this document use:
http://resolver.tudelft.nl/uuid:9f4d9c5c-0021-4fa5-b08d-eddd5fd4930d
DOI
https://doi.org/10.1093/bioinformatics/btw436
TNO identifier
573286
ISSN
1367-4803
Source
Bioinformatics, 32 (17), i473-i478
Document type
article