Title
Advanced REACH Tool (ART): Calibration of the mechanistic model
Author
Schinkel, J.
Warren, N.
Fransman, W.
van Tongeren, M.
McDonnell, P.
Voogd, E.
Cherrie, J.W.
Tischer, M.
Kromhout, H.
Tielemans, E.
Publication year
2011
Abstract
The mechanistic model of the Advanced Reach Tool (ART) provides a relative ranking of exposure levels from different scenarios. The objectives of the calibration described in this paper are threefold: to study whether the mechanistic model scores are accurately ranked in relation to exposure measurements; to enable the mechanistic model to estimate actual exposure levels rather than relative scores; and to provide a method of quantifying model uncertainty. Stringent data quality guidelines were applied to the collated data. Linear mixed effects models were used to evaluate the association between relative ART model scores and measurements. A random scenario and company component of variance were introduced to reflect the model uncertainty. Stratified analyses were conducted for different forms of exposure (abrasive dust, dust, vapours and mists). In total more than 2000 good quality measurements were available for the calibration of the mechanistic model. The calibration showed that after calibration the mechanistic model of ART was able to estimate geometric mean (GM) exposure levels with 90% confidence for a given scenario to lie within a factor between two and six of the measured GM depending upon the form of exposure. © 2011 The Royal Society of Chemistry.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Nutrition
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http://resolver.tudelft.nl/uuid:9f2d2b0a-da25-4b92-9315-df752b8da352
DOI
https://doi.org/10.1039/c1em00007a
TNO identifier
429732
ISSN
1464-0325
Source
Journal of Environmental Monitoring, 13 (5), 1374-1382
Document type
article