Print Email Facebook Twitter Advanced REACH Tool (ART): Calibration of the mechanistic model Title Advanced REACH Tool (ART): Calibration of the mechanistic model Author Schinkel, J. Warren, N. Fransman, W. van Tongeren, M. McDonnell, P. Voogd, E. Cherrie, J.W. Tischer, M. Kromhout, H. Tielemans, E. Publication year 2011 Abstract The mechanistic model of the Advanced Reach Tool (ART) provides a relative ranking of exposure levels from different scenarios. The objectives of the calibration described in this paper are threefold: to study whether the mechanistic model scores are accurately ranked in relation to exposure measurements; to enable the mechanistic model to estimate actual exposure levels rather than relative scores; and to provide a method of quantifying model uncertainty. Stringent data quality guidelines were applied to the collated data. Linear mixed effects models were used to evaluate the association between relative ART model scores and measurements. A random scenario and company component of variance were introduced to reflect the model uncertainty. Stratified analyses were conducted for different forms of exposure (abrasive dust, dust, vapours and mists). In total more than 2000 good quality measurements were available for the calibration of the mechanistic model. The calibration showed that after calibration the mechanistic model of ART was able to estimate geometric mean (GM) exposure levels with 90% confidence for a given scenario to lie within a factor between two and six of the measured GM depending upon the form of exposure. © 2011 The Royal Society of Chemistry. Subject LifeQS - Quality & SafetyEELS - Earth, Environmental and Life SciencesNutrition To reference this document use: http://resolver.tudelft.nl/uuid:9f2d2b0a-da25-4b92-9315-df752b8da352 DOI https://doi.org/10.1039/c1em00007a TNO identifier 429732 ISSN 1464-0325 Source Journal of Environmental Monitoring, 13 (5), 1374-1382 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.