Title
Hereditary cerebral hemorrhage with amyloidosis - Dutch type: A study of fibrinolysis
Author
Haan, J.
Kluft, C.
Leebeek, F.W.G.
de Bart, A.C.W.
Buruma, O.J.
Roos, R.A.C.
Publication year
1992
Abstract
In view of reported associations between increased bleeding tendency and systemically decreased alpha 2-antiplasmin in patients with systemic amyloid deposition we studied alpha 2-antiplasmin, fibrinogen, C-reactive protein and blood levels of locally produced endothelial hemostasis factors in the acute and quiescent phase in 16 patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). None of the factors measured in the quiescent phase of the disease was abnormal. In the acute phase, shortly after a stroke, only factor VIII:Ag was evidently elevated. We concluded that systemic abnormalities in the part of the fibrinolysis system studied are not likely to be responsible for multifocal and recurrent cerebral hemorrhages in HCHWA-D. The role of an elevated factor VIII:Ag level in the acute phase is unclear.
Subject
Health
Amyloidosis
C-Reactive Protein/metabolism
Blood
Cerebral Hemorrhage
Genetics
Factor VIII
Female
Fibrinolysis
Humans
Male
Middle Aged
metabolism
alpha-2-Antiplasmin
Factor VIII
Fibrinogen
C-Reactive Protein
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http://resolver.tudelft.nl/uuid:9ca0c730-09ec-4bd7-95dc-8f6a233728cf
TNO identifier
268299
Source
Thrombosis and haemostasis, 67 (1), 16-18
Document type
article