Title
Dentistry and OMICS: Transcriptome Dynamics of an Oral Ecosystem as Measured by Changes in Oral Polymorphonuclear Neutrophils in Experimental Gingivitis
Author
Rijkschroeff, P.
Schoenmaker, T.
Caspers, M.
Verschuren, L.
Keijser, B.J.F.
Nicu, E.A.
Loos, B.G.
Publication year
2020
Abstract
Oral health and dentistry are essential components of systems medicine, which has received lesser attention in comparison to other medical fields, such as cancer biology. In this context, oral polymorphonuclear neutrophils (oPMNs) play an important role in the maintenance of oral health. To the best of our knowledge, this is the first study to report original observations on the transcriptional responses of oPMNs during experimentally induced gingivitis, by temporarily refraining from regular oral care. Oral rinses were prospectively collected at four different time points for oPMNs isolation from healthy volunteers: day 1 (start of the experimental gingivitis challenge), day 9 (during challenge), day 14 (end of the challenge), and day 21 (postchallenge). Transcriptome of oPMNs was determined by RNA sequencing. Differentially expressed genes (DEGs) were selected at p
Subject
Dentistry
Gingivitis
Neutrophils
Ooral health
Transcriptomics
To reference this document use:
http://resolver.tudelft.nl/uuid:9a3075c6-5b86-4465-af24-bddba7917c97
DOI
https://doi.org/10.1089/omi.2020.0034
TNO identifier
880304
Source
Omics : Journal of Integrative Biology, 24 (24), 531-540
Document type
article