Title
Alcohol consumption and arterial stiffness in men
Author
Sierksma, A.
Muller, M.
van der Schouw, Y.T.
Grobbee, D.E.
Hendriks, H.F.J.
Bots, M.L.
TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2004
Abstract
Objective: Moderate alcohol consumption has been proposed to be anti-atherogenic and protect against coronary heart disease. Arterial stiffness provides a summary measure of atherosclerotic arterial damage and cardiovascular risk. A vascular protective effect of moderate alcohol consumption would be reflected in an inverse association between alcohol intake and aortic stiffness. Design: A cross-sectional study. Setting: The male population of Utrecht. Participants: Of 370 men, aged 40-80 years, alcohol intake was calculated from a standardized questionnaire and aortic stiffness was non-invasively assessed by pulse-wave velocity (PWV) measurement of the aorta. Results: There were no non-drinkers; therefore the group consuming 0-3 glasses of alcoholic beverage per week was chosen as the reference group in the analyses. Those drinking 4-10, 11-21 and 22-58 glasses of alcoholic beverage per week had a -0.77 m/s (95% confidence interval, -1.26 to -0.28), -0.57 m/s (95% confidence interval, -1.07 to -0.08) and -0.14 m/s (95% confidence interval, -0.65 to 0.36) difference in mean PWV compared with those drinking 0-3 glasses per week. Adjustment for factors that correlated with PWV or alcohol consumption did not change the strength of the association. Conclusion Among men aged 40-80 years there is a J-shaped association between alcohol consumption and PWV. This further supports a decreased risk of cardiovascular disease with moderate alcohol consumption. © 2004 Lippincott Williams & Wilkins.
Subject
Health
Physiological Sciences
Alcohol
Aortic stiffness
Men
Pulse-wave velocity
Adult
Aged
Alcohol consumption
Artery disease
Atherosclerosis
Cardiovascular risk
Confidence interval
Controlled study
Correlation analysis
Drinking behavior
Heart protection
Human
Human experiment
Ischemic heart disease
Male
Normal human
Population research
Priority journal
Pulse wave
Questionnaire
Aged
Aged, 80 and over
Alcohol Drinking
Alcoholic Beverages
Aorta
Confidence Intervals
Cross-Sectional Studies
Dose-Response Relationship, Drug
Elasticity
Humans
Male
Middle Aged
Pulse
Questionnaires
To reference this document use:
http://resolver.tudelft.nl/uuid:98aae294-a1a7-43a4-afb8-4754a6633914
DOI
https://doi.org/10.1097/00004872-200402000-00020
TNO identifier
237606
ISSN
0263-6352
Source
Journal of Hypertension, 22 (2), 357-362
Document type
article