Print Email Facebook Twitter Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer Title Methods for pooling results of epidemiologic studies: The pooling project of prospective studies of diet and cancer Author Smith-Warner, S.A. Spiegelman, D. Ritz, J. Albanes, D. Beeson, W.L. Bernstein, L. Berrino, F. van den Brandt, P.A. Buring, J.E. Cho, E. Colditz, G.A. Folsom, A.R. Freudenheim, J.L. Giovannucci, E. Goldbohm, R.A. Graham, S. Harnack, L. Horn-Ross, P.L. Krogh, V. Leitzmann, M.F. McCullough, M.L. Miller, A.B. Rodriguez, C. Rohan, T.E. Schatzkin, A. Shore, R. Virtanen, M. Willett, W.C. Wolk, A. Zeleniuch-Jacquotte, A. Zhang, S.M. Hunter, D.J. TNO Kwaliteit van Leven Publication year 2006 Abstract With the growing number of epidemiologic publications on the relation between dietary factors and cancer risk, pooled analyses that summarize results from multiple studies are becoming more common. Here, the authors describe the methods being used to summarize data on diet-cancer associations within the ongoing Pooling Project of Prospective Studies of Diet and Cancer, begun in 1991. In the Pooling Project, the primary data from prospective cohort studies meeting prespecified inclusion criteria are analyzed using standardized criteria for modeling of exposure, confounding, and outcome variables. In addition to evaluating main exposure-disease associations, analyses are also conducted to evaluate whether exposure-disease associations are modified by other dietary and nondietary factors or vary among population subgroups or particular cancer subtypes. Study-specific relative risks are calculated using the Cox proportional hazards model and then pooled using a random- or mixed-effects model. The study-specific estimates are weighted by the inverse of their variances in forming summary estimates. Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined. Copyright © 2006 by the Johns Hopkins Bloomberg School of Public Health All rights reserved. Subject HealthFood and Chemical Risk AnalysisCohort studiesDietEpidemiologic methodsMeta-analysisNeoplasmsanalytical methodcancerdietdisease incidenceepidemiologyhealth riskmeta-analysispopulation structurecancer epidemiologycancer registrycancer riskcohort analysisdietary intakeexposurehumanoutcome assessmentprospective studyreviewstandardizationstatistical analysisstatistical modelDietEpidemiologic MethodsHumansNeoplasmsProspective StudiesRisk FactorsStatistics To reference this document use: http://resolver.tudelft.nl/uuid:987aadaf-4eba-442b-94da-7e942188eceb DOI https://doi.org/10.1093/aje/kwj127 TNO identifier 239293 ISSN 0002-9262 Source American Journal of Epidemiology, 163 (11), 1053-1064 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.