Title
Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma
Author
TNO Preventie en Gezondheid Gaubius Instituut TNO
Sier, C.F.M.
Kubben, F.J.G.M.
Ganesh, S.
Heerding, M.M.
Griffioen, G.
Hanemaaijer, R.
van Krieken, J.H.J.M.
Lamers, C.B.H.W.
Verspaget, H.W.
Publication year
1996
Abstract
Proteinases are involved in tumour invasion and metastasis. Several matrix metalloproteinases (MMPs) have been shown to be increased in various human carcinomas. We assessed the levels of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in 50 gastric carcinomas and corresponding mucosa using quantitative gelatin zymography. Both MMP levels were significantly enhanced in gastric carcinomas compared with adjacent mucosal tissue, showed a relatively poor intercorrelation and no relation was found with histopathological carcinoma classifications according to Lauren, WHO and tumour-node-metastasis (TNM). Cox's multivariate proportional hazards analyses revealed that high carcinomatous MMP values are of prognostic significance for a poor overall survival of the patients, independent of the major clinicopathological parameters. Chemicals/CAS: Collagenases, EC 3.4.24.-; Gelatinases, EC 3.4.24.-; Matrix Metalloproteinase 2, EC 3.4.24.24; Matrix Metalloproteinase 9, EC 3.4.24.35; Metalloendopeptidases, EC 3.4.24.-
Subject
Gastric carcinoma
Gelatinases
Matrix metalloproteinase
Quantitative zymography
gelatinase b
proteinase
adult
cancer classification
cancer invasion
cancer survival
clinical article
controlled study
histopathology
human tissue
metastasis
priority journal
prognosis
stomach carcinoma
stomach mucosa
Aged
Collagenases
Female
Gelatinases
Humans
Male
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Metalloendopeptidases
Middle Aged
Stomach Neoplasms
Survival Rate
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TNO identifier
233424
ISSN
0007-0920
Source
British Journal of Cancer, 74 (74), 413-417
Document type
article