Print Email Facebook Twitter 13-Week oral toxicity study with isomaltulose (Palatinose®) in rats Title 13-Week oral toxicity study with isomaltulose (Palatinose®) in rats Author Jonker, D. Lina, B.A.R. Kozianowski, G. TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO Publication year 2002 Abstract The potential subchronic oral toxicity of isomaltulose (Palatinose®) was examined by administering this substance in the diet to groups of 20 male and 20 female Wistar rats at levels of 0, 2.5, 5 and 10% for 13 consecutive weeks. Daily clinical observations, body weight, food conversion efficiency, food and water consumption were not affected at any stage of the study. Ophthalmoscopy, haematology, clinical chemistry, urinalysis, organ weights, gross and histopathological examination, neurobehavioural observations, motor activity assessment and the results of an immunotoxicity screen did not reveal any abnormalities related to the ingestion of the test substance. In conclusion, the administration of isomaltulose at dietary levels up to 10% for 13 consecutive weeks was well tolerated without any signs of toxicity. The overall intake at this level corresponded to 7.0 and 8.1 g/kg body weight/day in male and female rats, respectively. © 2002 Elsevier Science Ltd. All rights reserved. Chemicals/CAS: Isomaltose, 499-40-1; isomaltulose, 13718-94-0 Subject Toxicology and Applied PharmacologyIsomaltuloseOral administrationRatSafetySubchronic toxicity studyPalatinoseAnimal experimentAnimal tissueBehaviorBlood analysisBody weightCarbohydrate analysisChronic toxicityClinical chemistryControlled studyDietFemaleFluid intakeFood analysisFood intakeHistopathologyImmunotoxicityIngestionMaleMotor activityNeurologic examinationNonhumanCphthalmoscopyOrgan weightRatSafetyUrinalysisAnimalsBlood CoagulationBody WeightDietEatingErythrocyte CountErythrocyte IndicesFemaleIsomaltoseLeukocyte CountMaleOrgan SizeRatsRats, WistarRattus norvegicus To reference this document use: http://resolver.tudelft.nl/uuid:97c41e2a-c38f-40c6-9ecc-68c441f91528 DOI https://doi.org/10.1016/s0278-6915(02)00106-0 TNO identifier 236722 ISSN 0278-6915 Source Food and Chemical Toxicology, 40 (10), 1383-1389 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.