Title
Alcohol intake and ovarian cancer risk: A pooled analysis of 10 cohort studies
Author
Genkinger, J.M.
Hunter, D.J.
Spiegelman, D.
Anderson, K.E.
Buring, J.E.
Freudenheim, J.L.
Goldbohm, R.A.
Harnack, L.
Hankinson, S.E.
Larsson, S.C.
Leitzmann, M.
McCullough, M.L.
Marshall, J.
Miller, A.B.
Rodriguez, C.
Rohan, T.E.
Schatzkin, A.
Schouten, L.J.
Wolk, A.
Zhang, S.M.
Smith-Warner, S.A.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Alcohol has been hypothesized to promote ovarian carcinogenesis by its potential to increase circulating levels of estrogen and other hormones; through its oxidation byproduct, acetaldehyde, which may act as a cocarcinogen; and by depletion of folate and other nutrients. Case-control and cohort studies have reported conflicting results relating alcohol intake to ovarian cancer risk. We conducted a pooled analysis of the primary data from ten prospective cohort studies. The analysis included 529 638 women among whom 2001 incident epithelial ovarian cases were documented. After study-specific relative risks (RR) and 95% confidence intervals (CI) were calculated by Cox proportional hazards models, and then were pooled using a random effects model; no associations were observed for intakes of total alcohol (pooled multivariate RR = 1.12, 95% CI 0.86-1.44 comparing ≥ 30 to 0 g day-1 of alcohol) or alcohol from wine, beer or spirits and ovarian cancer risk. The association with alcohol consumption was not modified by oral contraceptive use, hormone replacement therapy, parity, menopausal status, folate intake, body mass index, or smoking. Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings. This pooled analysis does not support an association between moderate alcohol intake and ovarian cancer risk. © 2006 Cancer Research. Chemicals / CAS: acetaldehyde, 75-07-0; folic acid, 59-30-3, 6484-89-5; Contraceptives, Oral
Subject
Health
Food and Chemical Risk Analysis
Alcohol
Ovarian cancer
Pooled analysis
acetaldehyde
carcinogen
estrogen
folic acid
hormone
oral contraceptive agent
adult
aged
alcohol consumption
article
beer
body mass
cancer incidence
cancer risk
carcinogenesis
cohort analysis
female
hormone substitution
human
major clinical study
ovary cancer
oxidation
priority journal
prospective study
wine
Adult
Aged
Aged, 80 and over
Alcohol Drinking
Body Mass Index
Cohort Studies
Contraceptives, Oral
Female
Hormone Replacement Therapy
Humans
Menopause
Middle Aged
Ovarian Neoplasms
Parity
Pregnancy
Risk Factors
To reference this document use:
http://resolver.tudelft.nl/uuid:9783d4a5-5057-43cb-aadc-87795d5f08be
DOI
https://doi.org/10.1038/sj.bjc.6603020
TNO identifier
239176
ISSN
0007-0920
Source
British Journal of Cancer, 94 (5), 757-762
Document type
article