Title
Ultrastructural changes in the kidneys of rabbits treated with lead acetate
Author
Centraal Instituut voor Voedingsonderzoek TNO
Spit, B.J.
Wibowo, A.A.E.
Ferron, V.J.
Zielhuis, R.L.
Publication year
1981
Abstract
Electron microscopical studies were carried out on the kidneys of rabbits given s.c. injections of 0 (control), 0.25 or 0.50 mg lead acetate/kg b.w. 3 times a week during 14 weeks. At the end of the experimental period the animals had lead blood levels of 60, 500 and 600 ??g/1 whole blood respectively. Treatment-related renal changes were found in the proximal tubules; they consisted of a dose-related increase in the amount of lysosomes in epithelial cells of the convoluted part, and of severely damaged cells and loss of brush border in the straight part. There was also an increase in lysosomal tubular inclusions, which are considered characteristic of lysosomes of the proximal tubular cells of the rabbit kidney. The significance of these findings for assessing the risk of occupational exposure to lead is briefly discussed. Chemicals/CAS: lead acetate, 15347-57-6, 301-04-2; lead, 7439-92-1; lead acetate, 301-04-2; Lead, 7439-92-1.
Subject
Lead
Lead acetate
Animal experiment
Histology
Kidney
Maximum allowable concentration
Mephrotoxicity
Animal
Dose-Response Relationship, Drug
Female
Kidney
Kidney Tubules, Proximal
Lead
Lead Poisoning
Male
Microscopy, Electron
Rabbits
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TNO identifier
229111
ISSN
0340-5761
Source
Archives of Toxicology, 49 (49), 85-91
Document type
article