Print Email Facebook Twitter Angiogenesis and anti-angiogenesis: Perspectives for the treatment of solid tumors Title Angiogenesis and anti-angiogenesis: Perspectives for the treatment of solid tumors Author van Hinsbergh, V.W.M. Collen, A. Koolwijk, P. Gaubius instituut TNO Publication year 1999 Abstract Angiogenesis is the formation of new blood vessels from preexisting ones. Many solid tumors depend on an extensive newly formed vascular network to become nourished and to expand. Tumor cells induce the formation of an extensive but aberrant vascular network by the secretion of angiogenic factors. A proper context is needed for the endothelial cells to respond. To create this proper context, the tumor often uses the body's own repair system to accelerate angiogenesis and the subsequent tumor expansion. The angiogenic response is governed by the interaction of angiogenic growth factors and cytokines with specific receptors on the endothelium, as well as by the interaction of these cells with their surrounding matrix, which is regulated by matrix-degrading proteases and adhesion molecules such as integrins. A number of agents have been discovered and developed that aim to inhibit angiogenesis and to convert the tumor to a dormant state. They have proven to be effective in animal studies. At present their efficacy in man is under evaluation. Subject BiologyAngiogenesisAngiogenesis inhibitionAngiogenic growth factorsEndotheliumMatrix-degrading proteasesPancreasHumansNeoplasmsNeovascularization, PathologicPancreatic Neoplasms To reference this document use: http://resolver.tudelft.nl/uuid:9699c146-3763-4303-a10b-71df119e3bd3 TNO identifier 235097 ISSN 0923-7534 Source Annals of Oncology, 10 (SUPPL. 4) Document type article Files To receive the publication files, please send an e-mail request to TNO Library.