Title
Evaluation of the sensory irritation test (alarie test) for the assessment of respiratory tract irritation
Author
Bos, P.M.J.
Busschers, M.
Arts, J.H.E.
Instituut CIVO-Toxicologie en Voeding TNO
Publication year
2002
Abstract
Within the framework of risk assessment of existing substances in the EC the irritating properties on the respiratory tract should be considered. Since no standardized test is available it was studied whether the Alarie test could be used for this purpose, as proposed by the Technical Guidance Document for new and existing substances. The available literature on respiratory tract irritation, seen as a local inflammatory response and/or tissue damage, after single and repeated (few-day) exposure was evaluated and compared with data on sensory irritation. No relation was found between the sensory irritation potential (as measured by the Alarie test) and local tissue damage (histopathological changes) in the respiratory tract after single or repeated exposure. It was concluded that the Alarie test is inappropriate to evaluate respiratory tract irritation. In addition, the available data do not support a quantitative potency ranking for man based on the RD50 obtained with experimental animals. Chemicals/CAS: Air Pollutants; Irritants
Subject
Environment
Administration, Inhalation
Air Pollutants
Animals
Bronchial Hyperreactivity
Dose-Response Relationship, Drug
Irritants
Mice
Models, Animal
Nasal Mucosa
Rats
Rats, Wistar
Reproducibility of Results
Respiratory Tract Diseases
Sensation
Sensitivity and Specificity
Species Specificity
Animalia
To reference this document use:
http://resolver.tudelft.nl/uuid:968faa37-d598-41a8-a4d6-77c691a466bf
TNO identifier
87762
ISSN
1076-2752
Source
Journal of Occupational and Environmental Medicine, 44 (10), 968-976
Document type
article