Print Email Facebook Twitter Rescuing drug discovery: In vivo systems pathology and systems pharmacology Title Rescuing drug discovery: In vivo systems pathology and systems pharmacology Author van der Greef, J. McBurney, R.N. TNO Kwaliteit van Leven Publication year 2005 Abstract The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been brought into question. Here, we discuss whether taking an in vivo systems approach to drug discovery and development could be the paradigm shift that rescues the industry. Subject Pharmacology HealthAnalytical research5' methoxyhydnocarpinberberinebiological markerginseng extractherbaceous agentHypericum extractparoxetineunclassified drugarticlebioinformaticscardiovascular diseaseclinical trialcost benefit analysiscost controlcost effectiveness analysisdata basedepressiondrug approvaldrug designdrug efficacydrug indicationdrug industrydrug informationdrug marketingdrug researchdrug responsedrug safetydrug screeningdrug targetinggrowth inhibitionhealth carehealth care costhealth programhumanin vivo studynon insulin dependent diabetes mellitusnonhumanpatient compliancepredictionprescriptionpriority journalproductivityquantitative analysisstandardsystem analysisvalidation processanimaldiagnosiseconomicsmass communicationreviewAnimalsCost-Benefit AnalysisDiagnosisDiffusion of InnovationDrug ApprovalDrug DesignDrug EvaluationDrug Evaluation, PreclinicalDrug IndustryHumans To reference this document use: http://resolver.tudelft.nl/uuid:964742a4-50fc-45b5-97d4-158693fa44cc DOI https://doi.org/10.1038/nrd1904 TNO identifier 238972 ISSN 1474-1776 Source Nature Reviews Drug Discovery, 4 (12), 961-967 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.