Title
Respiratory tract tumors in hamsters after severe focal injury to the trachea and intratracheal instillation of benzo[a]pyrene
Author
Reynders, J.B.J.
Immel, H.R.
Scherrenberg, P.M.
Feron, V.J.
Beems, R.B.
Instituut CIVO-Toxicologie en voeding TNO
Publication year
1985
Abstract
Two groups of male and female Syrian golden hamsters, of which the trachea was severely injured by electrocoagulation, received 6 weekly intratracheal instillations of benzo[a]pyrene (BaP) + ferric oxide in saline or saline alone. Two comparable groups of hamsters were similarly treated but had an undamaged trachea. The experiment was terminated in week 82. Treatment with BaP resulted in hyper- and metaplastic lesions and tumours of the laryngeal, tracheal, bronchial and pulmonary epithelium. There was no evidence of an increased incidence of BaP-induced tumours in the injured trachea. Chemicals/CAS: benzo[a]pyrene, 50-32-8; Benzo(a)pyrene, 50-32-8
Subject
Benzo[a]pyrene
Animal experiment
Animal model
Controlled study
Electrocoagulation
Etiology
Hamster
Histology
Injury
Nonhuman
Priority journal
Respiratory system
Respiratory tract cancer
Therapy
Trachea
Animal
Benzo(a)pyrene
Body Weight
Bronchial Neoplasms
Cocarcinogenesis
Electrocoagulation
Female
Hamsters
Hyperplasia
Laryngeal Neoplasms
Lung Neoplasms
Male
Mesocricetus
Respiratory Tract Neoplasms
Support, Non-U.S. Gov't
Trachea
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TNO identifier
229886
ISSN
0304-3835
Source
Cancer Letters, 29 (1), 93-99
Document type
article