Title
Reduction of polyneuronal innervation of muscle cells in tissue culture after long-term indirect stimulation
Author
Magchielse, T.
Meeter, E.
Medisch Biologisch Laboratorium TNO
Publication year
1982
Abstract
In combined cultures of chick muscle cells and ciliary ganglia, the effect of indirect, long-term stimulation on the number of neuromuscular contacts on individual muscle cells was studied. Seven days of phasic stimulation resulted in a marked reduction in the number of neuromuscular contacts, the majority of the muscle cells becoming innervated by only one neuron. Neuromuscular blockade by D-tubocurarine prevented this loss of innervation. Chemicals/CAS: tubocurarine chloride, 57-94-3, 57-95-4, 8006-51-7
Subject
Biology
Tubocurarine chloride
Animal experiment
Chicken
Ciliary ganglion
Electrostimulation
In vitro study
Innervation
Muscle
Muscle cell
Muscle innervation
Nervous system
Neuromuscular transmission
Peripheral nervous system
Tissue culture
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TNO identifier
229177
ISSN
0165-3806
Source
Developmental Brain Research, 3 (1), 130-133
Document type
article