Title
Animal studies using an oxygen-tension sensor for tissue viability monitoring
Author
Tanase, D.
Komen, N.
Draaijer, A.
Lange, J.F.
Kleinrensink, G.J.
Jeekel, J.
French, P.J.
TNO Kwaliteit van Leven
KvL
Publication year
2008
Abstract
Leakage at the site of an anastomosis is the main, yet unsolved reason for mortality in abdominal surgery. Every year, a large number of patients die due to anastomotic leakage after surgery. An objective aid to monitor the anastomotic site pre- and postoperatively and detect leakage at an early stage, is needed. Therefore, a miniature, wireless measurement system to detect tissue viability during and after colon surgery (continuously for 7 days) is being developed. The complete sensor chip should include an oxygen- saturation sensor (sO2) an oxygen-tension sensor (pO2) a carbon-dioxide tension sensor (pCO2)and a temperature sensor. The present work focuses on the use of the oxygen-tension and temperature sensors for animal studies. Initial in-vivo measurements were carried out on the small and large intestines of male wistar rats. The main goal was to measure the distribution of pO2 on the colon around the anastomosis and to determine the changes in pO2 during repetitive ischemia-and-reperfiision experiments on the small intestine. The paper presents the obtained measurement results.
Subject
Biology
Colon
Optical method
Oxygen-tension sensor
Tissue viability
To reference this document use:
http://resolver.tudelft.nl/uuid:952713dc-a695-4682-939b-613e235de6ba
TNO identifier
242708
ISBN
9789898111173
Source
BIODEVICES 2008 - 1st International Conference on Biomedical Electronics and Devices, 28 January 2008 through 31 January 2008, Funchal, Madeira. Conference code: 73993, 1, 50-55
Series
BIODEVICES 2008 - Proceedings of the 1st International Conference on Biomedical Electronics and Devices
Document type
conference paper